histone-lysine N-methyltransferase EZH1; ENX-2; enhancer of zeste homolog 1 (EZH1, KIAA0388)

Function: - polycomb group (PcG) protein - catalytic subunit of the PRC2/EED-EZH1 complex, which methylates Lys-27 of histone H3, leading to transcriptional repression of the affected target gene(s) - required for embryonic stem cell derivation & self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity Structure: - belongs to the histone-lysine methyltransferase family, EZ subfamily - contains 1 SET domain Compartment: - nucleus - colocalizes with trimethylated Lys-27 of histone H3 Alternative splicing: named isoforms=5

General

methyltransferase transcriptional silencer (transcriptional repressor)

Properties

SIZE: entity length = 747 aa MW = 85 kD COMPARTMENT: cell nucleus MOTIF: nuclear translocation signal {491-496} cysteine-rich region {524-606} SET domain {612-732}

Database Correlations

OMIM 601674 UniProt Q92800 PFAM correlations Entrez Gene 2145 Kegg hsa:2145 ENZYME 2.1.1.43

References

UniProt :accession Q92800