exosome complex exonuclease RRP45 (polymyositis/scleroderma autoantigen 1, autoantigen PM/Scl 1, polymyositis/scleroderma autoantigen 75 kD, PM/Scl-75, P75 polymyositis-scleroderma overlap syndrome associated autoantigen, EXOSC9, PMSCL1)

Function: - component of the exosome 3'->5' exoribonuclease complex - also associated with the GTPase Ran (putative) Structure: belongs to the Rnase PH family Compartment: cytoplasm, nucleus, nucleolus Alternative splicing: named isoforms=4 Pathology: - autoantibody in patients with polymyositis & scleroderma or with overlap of these two conditions Laboratory: - PM-SCL-75 Ab in serum

Related

polymyositis scleroderma (diffuse cutaneous systemic sclerosis)

General

nuclear protein phosphoprotein protein subunit

Properties

SIZE: entity length = 439 aa MW = 49 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: Ser phosphorylation site {S392} Ser phosphorylation site {S394}

Database Correlations

OMIM 606180 UniProt Q06265 PFAM correlations

References

UniProt :accession Q06265