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5'-3' exoribonuclease 2 ( DHM1-like protein, DHP protein, XRN2)
Function:
- possesses 5'->3' exoribonuclease activity
- may promote the termination of transcription by RNA polymerase 2 (during transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA & a 3' fragment which remains attached to the elongating RNA polymerase 2; processive degradation of this 3' fragment by XRN2 may promote termination of transcription)
- exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates
Structure:
- belongs to the 5'-3' exonuclease family, XRN2/RAT1 subfamily
- contains 1 CCHC-type Zn+2 finger
Compartment: nucleus, nucleolus
Alternative splicing: named isoforms=2
Expression:
- expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, & pancreas
- isoform 2 is expressed predominantly in peripheral blood leukocytes
General
exoribonuclease
zinc finger protein
Properties
SIZE: entity length = 950 aa
MW = 109 kD
COMPARTMENT: cell nucleus
MOTIF: Zn finger C2HC-type
SITE: 262-278
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S448}
Ser phosphorylation site {S455}
Ser phosphorylation site {S499}
Ser phosphorylation site {S501}
Database Correlations
UniProt Q9H0D6
Pfam PF03159
References
UniProt :accession Q9H0D6