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Et translocation variant 1; ER81 protein; Ets-related variant 1 (ETV1)
Function:
- transcriptional activator
- binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'
- sumoylated
Structure:
- belongs to the ETS family
- contains 1 ETS DNA-binding domain
Compartment: nucleus (probable)
Alternative splicing: named isoforms=2
Expression:
- expressed in brain > testis, lung & heart > spleen, small intestine, pancreas & colon > liver, prostate, thymus > skeletal muscle, kidney & ovary
- not expressed in placenta & peripheral blood leukocytes
Pathology:
- chromosomal translocation t(7;22)(p22;q12) involving ETV1 with EWS is a cause of Ewing sarcoma
General
Ets family protein
Properties
SIZE: entity length = 477 aa
MW = 55 kD
COMPARTMENT: cell nucleus
MOTIF: ETS domain
NAME: ETS domain
SITE: 335-415
Database Correlations
OMIM correlations
UniProt P50549
PFAM correlations
Entrez Gene 2115
Kegg hsa:2115
References
- Entrez Gene :accession 2115
- UniProt :accession P50549