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ets2 proto-oncogene protein; protein C-ets-2 (ETS2)
Function:
- required for meiotic maturation of oocytes
Structure:
- belongs to the ETS family
- translation product of alternatively spliced transcript of c-ets
- contains 1 ETS DNA-binding domain
- contains 1 PNT (pointed) domain
Compartment: nucleus
Expression:
- induced following macrophage differentiation & T-cell activation
Interactions
molecular events
Related
ets2 proto-oncogene
General
Ets family protein
Properties
SIZE: MW = 58 kD
MW = 62 kD
COMPARTMENT: cell nucleus
MOTIF: ETS domain
NAME: ETS domain
phosphorylation site
Database Correlations
OMIM 164740
UniProt P15036
PFAM correlations
Entrez Gene 2114
Kegg hsa:2114
References
- Macleod K, Leprince D, Stehelin D.
The ets gene family.
Trends Biochem Sci. 1992 Jul;17(7):251-6. Review.
PMID: 1502727
- Chen ZQ, Burdett LA, Seth AK, Lautenberger JA, Papas TS.
Requirement of ets-2 expression for Xenopus oocyte maturation.
Science. 1990 Dec 7;250(4986):1416-8.
PMID: 2255913
- Entrez Gene :accession 2114
- UniProt :accession P15036