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ets1 proto-oncogene protein; protein C-ets-1; p54 (ETS1, EWSR2)
Function:
- transcription factor
- binds to DAXX
- interacts with UBE2I
- sumoylated on Lys-15 & Lys-227, preferentially by SUMO2 which inhibits transcriptional activity (putative)
- ubiquitinated; which induces proteasomal degradation
Structure:
- belongs to the ETS family
- contains 1 ETS DNA-binding domain
- contains 1 PNT (pointed) domain
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression:
- elevated expression in thymus & endothelial cells
- positively autoregulates transcription of its gene
Pathology:
- ETS is responsible for erythroblast & fibroblast transformation
- juxtaposition of the interferon & c-ETS-1 proto-oncogene may be involved in the pathogenesis of monocytic leukemia
Interactions
molecular events
Related
ets1 proto-oncogene
Specific
ets1A proto-oncogene protein
ets1B proto-oncogene protein
General
Ets family protein
phosphoprotein
Properties
SIZE: entity length = 441 aa
MW = 50 kD
COMPARTMENT: cell nucleus
MOTIF: Thr phosphorylation site {T38}
PNT {53-136}
Tyr phosphorylation site {Y205}
Tyr phosphorylation site {Y223}
ETS domain
NAME: ETS domain
SITE: 335-415
Database Correlations
OMIM 164720
UniProt P14921
PFAM correlations
Entrez Gene 2113
Kegg hsa:2113
References
- Ho IC, Bhat NK, Gottschalk LR, Lindsten T, Thompson CB,
Papas TS, Leiden JM.
Sequence-specific binding of human Ets-1 to the T cell
receptor alpha gene enhancer.
Science. 1990 Nov 9;250(4982):814-8.
PMID: 2237431
- Macleod K, Leprince D, Stehelin D.
The ets gene family.
Trends Biochem Sci. 1992 Jul;17(7):251-6. Review.
PMID: 1502727
- Bories JC et al
Increased T-cell apoptosis and terminal B-cell differentiation
induced by inactivation of the Ets-1 proto-oncogene.
Nature. 1995 Oct 19;377(6550):635-8.
PMID: 7566176
- Entrez Gene :accession 2113