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etodolac (Lodine)
Tradename Lodine.
Indications:
- temporary relief of minor aches, pains, fever & inflammation
- osteoarthritis, bursitis,
- not as effective as other NSAIDs for rheumatoid arthritis
Dose: 200-400 mg PO TID/QID, max 1200 mg/day.
Tabs: 200, 300, 400 mg.
Pharmacokinetics:
1) well absorbed, onset of action 30 min-1 hour
2) volume of distribution L/kg
3) highly protein bound
4) elimination 1/2life is about 7 hours
Adverse effects:
1) GI distress
2) GI bleeding
3) nausea
4) headache
5) nephrotoxicity (by analogy to celecoxib & rofecoxib)
Drug interactions:
1) corticosteroids
a) increased clearance of salicylates
b) in combination increase renal & GI toxicity
2) etodolac may decrease antihypertensive effects of ACE inhibitors
3) in combination with warfarin may increase bleeding time
4) etodolac may increase methotrexate levels & toxicity
Mechanism of action:
1) non known, but presumed to inhibit cyclooxygenase
-> some selectivity for inhibition of COX-2 [4]
2) analgesic, antipyretic & anti-inflammatory
Interactions
drug interactions
drug adverse effects of NSAIDs
monitor with non steroidal anti-inflammatory agents (NSIADs)
General
non-steroidal anti-inflammatory agent (NSAID)
Properties
INHIBITS: cyclooxygenase
MISC-INFO: elimination route LIVER
1/2life 3.3-11.3 HOURS
pregnancy-category C
safety in lactation -
Database Correlations
PUBCHEM cid=3308
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998
- Kaiser Permanente Northern California Regional Drug
Formulary, 2000
- Prescriber's Letter 12(3): 2005
- Geriatric Dosage Handbook, 6th edition, Selma et al eds,
Lexi-Comp, Cleveland, 2001