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ethinyl estradiol/drosperinone (Ocella, Yasmin, Gianvi, Vestura)

Indications: - Combination monophasic oral contraceptive. Contraindications: Cautions: 1) patients at risk of hyperkalemia a) renal insufficiency b) hepatic insufficiency c) adrenal insufficiency 2) NOT a weight-loss agent [2] Dosage: ethinyl estradiol: 30 ug drospirenone: (progestin with antimineralocorticoid activity) Adverse effects: - drospirenone may increase serum K+ levels [4] - drospirenone may increase of venous thromboembolism [5] Drug interactions: - concurrent administration agents increasing serum K+ 1] ACE inhibitors 2] angiotensin II receptor antagonists 3] K+ sparing diuretics 4] K+ supplements 5] NSAIDs 6] salt substitutes Notes: Manufacturer: Berlex (Yasmin)

Interactions

drug adverse effects of estrogens

General

monophasic oral contraceptive estrogen/progestin

Database Correlations

PUBCHEM cid=147740

References

  1. Prescriber's Letter 8(6):34 2001
  2. Prescriber's Letter 9(2):S1 2002
  3. Prescriber's Letter 9(11):63 2002
  4. Prescriber's Letter 16(10): 2009 Safety of Drospirenone-Containing Oral Contraceptives Detail-Document#: 251007 (subscription needed) http://www.prescribersletter.com
  5. FDA Safety Alert: Posted 05/31/2011 Birth Control Pills Containing Drospirenone: Possible Increased Risk of Blood Clots http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm257337.htm
  6. Wikipedia: Ethinylestradiol/drospirenone https://en.wikipedia.org/wiki/Ethinylestradiol/drospirenone

Components

drosperinone ethinyl estradiol