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ethchlorvynol (Placidyl)
Tradename: Placidyl. DEA-controlled substance: class 4.
Dosage: 500 mg PO QHS.
Tabs: 200, 500, 750 mg.
Pharmacokinetics:
1) extensive distribution to adipose tissue
2) biphasic elimination
Adverse effects:
1) dizziness
2) nausea/vomiting
3) hypotension
4) respiratory depression, bradycardia, hypothermia with overdose
Laboratory:
- ethchlorvynol in specimen
- ethchlorvynol in body fluid
- ethchlorvynol in blood
- ethchlorvynol in bile fluid
- ethchlorvynol in gastric fluid
- ethchlorvynol in serum/plasma
- ethchlorvynol in urine
Interactions
drug adverse effects (more general classes)
General
sedative/hypnotic (tranquilizer)
Properties
MISC-INFO: elimination route LIVER
KIDNEY
1/2life 10-20 HOURS
therapeutic-range 2-8 UG/ML
toxic-range >20 UG/ML
protein-binding 60%
elimination by hemodialysis -
hemoperfusion +
peritoneal dialysis -
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995