protein SMG5 (SMG-5 homolog, EST1-like protein B, LPTS-interacting protein, LPTS-RP1, SMG5, EST1B, KIAA1089)

Function: 1) role in nonsense-mediated mRNA decay 2) promotes dephosphorylation of RENT1 3) necessary for TERT activity 4) interacts with TERT, PP2AC & SMG1 5) component of a complex that contains SMG1, SMG5, SMG7, PP2AC, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) & phosphorylated RENT1 - not detected in complexes that contain unphosphorylated RENT1 6) detected in cytoplasmic mRNA decay bodies Structure: contains 1 PINc domain Compartment: - cytoplasm, nucleus - shuttles between nucleus & cytoplasm Expression: ubiquitous

Properties

SIZE: MW = 114 kD entity length = 1016 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: arginine-rich region {460-463} MOTIF: arginine residue (SEVERAL) glutamate-rich region {529-532} MOTIF: glutamate residue (SEVERAL) coiled coil {798-841} PINc {872-995}

References

UniProt :accession Q9UPR3