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estrogen-related receptor gamma; estrogen receptor-related protein 3; ERR gamma-2; nuclear receptor subfamily 3 group B member 3 (ESRRG, ERR3, ERRG2, KIAA0832, NR3B3)
Function:
- orphan receptor
- no physiological activating ligand is known
- acts as transcription activator in the absence of bound ligand
- binds specifically to an estrogen response element & activates reporter genes controlled by estrogen response elements (putative)
- sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 & represses transcriptional activity
- phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity
- binds TLE1, PNRC1 & PNRC2
- binds GRIP1
- interacts with NRIP1, NCOA1 & NCOR2
Inhibition:
- 4-hydroxytamoxifen & diethylstilbestrol act as antagonists & deactivate ESRRG
Structure:
- homodimer
- belongs to the nuclear hormone receptor family, NR3 subfamily
- contains 1 nuclear receptor DNA-binding domain
Compartment: nucleus (probable)
Alternative splicing: named isoforms=3
Expression:
- expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord & thyroid gland
- expressed at high levels in fetal brain, kidney, lung & liver
General
human longevity protein
phosphoprotein
steroid receptor
zinc finger protein
Properties
SIZE: entity length = 458 aa
MW = 51 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S45}
DNA-binding motif
SITE: 125-200
MOTIF: Zn finger C4-type
SITE: 128-148
EFFECTOR-BOUND: Zn+2
Zn finger C4-type
SITE: 164-188
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 602969
UniProt P62508
PFAM correlations
Kegg hsa:2104
References
- UniProt :accession P62508
- NIEHS-SNPs
http://egp.gs.washington.edu/data/esrrg/