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steroid hormone receptor ERR1; estrogen-related receptor, alpha; ERR-alpha; estrogen receptor-like 1; nuclear receptor subfamily 3 group B member 1 (ESRRA, ERR1, ESRL1, NR3B1)
Function:
- binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'
- can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 & may act as a regulator of the MCAD promoter
- binds to the C1 region of the lactoferrin gene promoter
- requires dimerization & the coactivator, PGC-1A, for full activity
- ERRalpha/PGC1alpha complex is a regulator of energy metabolism
- binds DNA as a monomer or a homodimer
- interacts (via the AF2 domain) with coactivator PPARGC1A (via the L3 motif); the interaction greatly enhances transriptional activity of genes
- role in energy metabolism
- interacts with PIAS4
- sumoylated by SUMO2
a) main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, & by interaction with PIAS4
b) sumoylation enhances repression of transcriptional activiy, but has no effect on subcellular location nor on DNA binding
Structure:
- belongs to the nuclear hormone receptor family, NR3 subfamily
- contains 1 nuclear receptor DNA-binding domain
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression:
- induced by PGC1alpha in a number of specific cell types including heart, kidney & muscle
General
phosphoprotein
steroid receptor
zinc finger protein
Properties
SIZE: entity length = 423 aa
MW = 46 kD
COMPARTMENT: cell nucleus
MOTIF: Repressor {1-76}
MOTIF: Ser phosphorylation site {S19}
Ser phosphorylation site {S22}
Ser phosphorylation site {S27}
DNA-binding motif
SITE: 76-151
MOTIF: Zn finger C4-type
SITE: 79-99
EFFECTOR-BOUND: Zn+2
Zn finger C4-type
SITE: 115-134
EFFECTOR-BOUND: Zn+2
threonine residue {124}
Ligand binding {206-402}
AF-2 {403-423}
Database Correlations
OMIM 601998
UniProt P11474
PFAM correlations
Kegg hsa:2101
References
UniProt :accession P11474