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estrogen receptor-1; estrogen receptor-alpha; ER; estradiol receptor; ER-alpha; nuclear receptor subfamily 3 group A member 1 (ESR1, ESR, NR3A1)

Function: - nuclear hormone receptor - cytoplasmic anchoring &/or assembly associated with heat shock proteins hsp70 & hsp90 & immunophilin p59FKBP - interacts with SLC30A9 (putative) - binds DNA as a homodimer - can form a heterodimer with ESR2 - interacts with NCOA3, NCOA5 & NCOA6 coactivators, leading to a strong increase of transcription of target genes - interacts with NCOA7 in a ligand-inducible manner - interacts with PHB2, PELP1 & UBE1C - interacts with AKAP13 - interacts with CUEDC2 - interacts with JARID1A - interacts with SMARD1 - interacts with HEXIM1 & MAP1S - interacts with PBXIP1 - interaction with MUC1 is stimulated by 17 beta-estradiol (E2) & enhances ERS1-mediated transcription - interacts with DNTTIP2 & FAM120B - interacts with isoform 4 of TXNRD1 - interacts with MLL2 - interacts with ATAD2; interaction enhanced by estradiol - phosphorylated by cyclin A/CDK2 - phosphorylation probably enhances transcriptional activity Structure: - glycosylated; contains N-acetylglucosamine, probably O-linked - composed of three domains: a modulating N-terminal domain, a DNA-binding domain & a C-terminal steroid-binding domain - belongs to the nuclear hormone receptor family, NR3 subfamily - contains 1 nuclear receptor DNA-binding domain Compartment: nucleus Alternative splicing: named isoforms=2 Expression: 1) breast 2) bone 3) reproductive organs 4) liver [3] 5) brain [3] 6) cardiovascular system [3] Polymorphism: - genetic variations in ESR1 are correlated with bone mineral density (BMD)

Interactions

molecular events

Related

estrogen selective estrogen receptor modulator (SERM)

General

estrogen receptor PEST protein

Properties

SIZE: entity length = 595 aa MW = 66 kD COMPARTMENT: cell nucleus MOTIF: Modulating {1-184} MOTIF: Thr phosphorylation site {T7} Ser phosphorylation site {S10} Ser glycosylation site {S10} Ser phosphorylation site {S104} Ser phosphorylation site {S106} Ser phosphorylation site {S118} Ser phosphorylation site {S167} domain {185-310} MOTIF: DNA-binding motif SITE: 185-250 Zn finger C4-type SITE: 185-205 EFFECTOR-BOUND: Zn+2 Zn finger C4-type SITE: 221-245 EFFECTOR-BOUND: Zn+2 Hinge {251-310} AKAP13 interaction {262-595} MOTIF: ligand-binding site SITE: 311-551 FOR-BINDING-OF: estrogen Tyr phosphorylation site {Y537}

Database Correlations

OMIM 133430 UniProt P03372 PFAM correlations Entrez Gene 2099 Kegg hsa:2099

References

  1. Alberts et al Molecular Biology of the Cell, 2nd ed. 1989, pg 704
  2. Wang KK et al Calmodulin-binding proteins as calpain substrates. Biochem J 262:693 1989 PMID: 2556106
  3. Journal Watch 22(5):39, 2002 Zhu Y et al, Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Science. 2002 Jan 18;295(5554):505-8. PMID: 11799247
  4. Entrez Gene :accession 2099
  5. Uniprot :accession P03372
  6. Wikipedia; Note: estrogen receptor entry http://en.wikipedia.org/wiki/estrogen_receptor