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esomeprazole (Nexium)
Tradename: Nexium. Generic approved Jan 2015 [3]
S-isomer of omeprazole (racemic mixture of S & R isomers).
Dosage:
- 20-40 mg QD 1 hour before meals
Capsules: 20 & 40 mg (OK to open capsule & mix with a small amount of applesauce)
Nexium IV for intravenous infusion
Pharmacokinetics:
-> both S & R isomers (omeprazole) are effective, but the S-isomer (esomeprazole) is metabolized more slowly
Adverse effects:
- see omeprazole
- hypomagnesemia ?
Interactions
drug interactions
drug adverse effects of proton pump inhibitors (PPI)
General
omeprazole (Prilosec, Zegerid, Losec, Medral)
Properties
INHIBITS: H+/K+ ATPase
MISC-INFO: elimination route LIVER
1/2life 0.5-1.5 HOURS
protein-binding 95%
pregnancy-category C
safety in lactation ?
Database Correlations
PUBCHEM correlations
References
- Prescriber's Letter 8(1):1 2001
- Prescriber's Letter 8(3):13 2001
- Brooks M
FDA Clears First Generic Esomeprazole for GERD.
Medscape. Jan 26, 2015
http://www.medscape.com/viewarticle/838739
- FDA News Release. January 26, 2015
FDA approves first generic esomeprazole.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm431648.htm