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ergoloid mesylates (Hydergine)
Tradename: Hydergine.
Indications:
Hydergine is used for the relief of signs & symptoms of idiopathic decline in mental capacity, including: mood, self- care, motivation, sociability, cognitive skills in geriatric patients. The magnitude of beneficial effects is small.
Dosage:
Alzheimer's disease:
- Start 1 mg PO TID, max 12 mg/day.
Tabs: 0.5 & 1 mg.
Liquid: 1 mg/mL.
Pharmacokinetics:
1) 1st pass metabolism in liver with < 50% of drug reaching systemic circulation
2) metabolized by liver
3) < 2% excreted in the urine
4) presumably excreted in the feces
5) 1/2life (biphasic):
a) t1/2(alpha): 4.1 hours
b) t1/2(beta): 12 hours
Adverse effects: (infrequent, no serious reactions)
1) rash
2) nasal congestion
3) blurred vision
4) orthostatic hypotension
5) flushing
6) sinus bradycardia
7) anorexia
8) lightheadedness
9) nausea
General
ergot alkaloid
nootropic agent
pharmaceutical agents for treatment of Alzheimer's disease (Alzheimer's agent)
Database Correlations
PUBCHEM cid=592735
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- AHFS 96 Drug Information, GK McEnvoy et al (ed),
American Society of Health-System Pharmacists,
Bethesda, MD 1996, pg 919
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998