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erg proto-oncogene protein
Function:
- transcriptional regulator
- may participate in transcriptional regulation through recruitment of SETDB1 histone methyltransferase & subsequent modification of local chromatin structure
- interacts with SETDB1 (putative)
Structure:
- belongs to the ETS family
- 98% homologous to fli-1 protein
- contains 1 ETS DNA-binding domain
- contains 1 PNT (pointed) domain
Compartment: nucleus
Alternative splicing: named isoforms=6
Pathology:
- chromosomal translocation t(21;22)(q22;q12) involving ERG with ERW is a cause of Erwing sarcoma
- chromosomal translocation t(16;21)(p11;q22) involving ERG with FUS is a cause of acute myeloid leukemia
Related
erg proto-oncogene
Specific
erg proto-oncogene protein-1
erg proto-oncogene protein-2
General
Ets family protein
Properties
SIZE: entity length = 486 aa
MW = 55 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S93}
PNT {122-206}
ETS domain
NAME: ETS domain
SITE: 318-398
Database Correlations
OMIM correlations
UniProt P11308
PFAM correlations
Kegg hsa:2078
References
- Macleod K, Leprince D, Stehelin D.
The ets gene family.
Trends Biochem Sci. 1992 Jul;17(7):251-6. Review.
PMID: 1502727
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/ERGID53ch21q22.htm
- UniProt :accession P11308
Component-of
mRNP granule complex