epidermal growth factor receptor kinase substrate 8 (EPS8)

Function: - upon binding to EGF receptor, enhances EGF-dependent mitogenic signals - can bind multiple cellular targets - phosphorylated by several receptor tyrosine kinases - homodimer (putative) - interacts with LANCL1 - interacts with BAIAP2 - interacts with SHB Structure: - the SH3 domain mediates interaction with SHB - belongs to the EPS8 family - contains 1 PH domain - contains 1 SH3 domain Expression: - expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney & pancreas - expressed in all epithelial & fibroblastic lines analyzed - expressed in some, but not all, hematopoietic cells

Properties

SIZE: entity length = 822 aa MW = 92 kD MOTIF: PH; first part {69-129} PH; second part {381-414} proline-rich region SITE: 421-440 MOTIF: proline residue (SEVERAL) Tyr phosphorylation site {Y485} Tyr phosphorylation site {Y525} src homology 3 [SH3] domain SITE: 531-590 proline-rich region SITE: 615-651 MOTIF: proline residue (SEVERAL) serine-rich region {659-664} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S659} Ser phosphorylation site {S661} Ser phosphorylation site {S662} Tyr phosphorylation site {Y774} Ser phosphorylation site {S811} Ser phosphorylation site {S815}

Database Correlations

OMIM 600206 UniProt Q12929 PFAM correlations Entrez Gene 2059 Kegg hsa:2059

References

UniProt :accession Q12929