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epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein, Eps15R, EPS15L1, EPS15R)
Function:
- constitutive component of clathrin-coated pits
- required for receptor-mediated endocytosis
- interacts with EPS15, HRB & HRBL
- associates with clathrin-associated adapter protein complex 2 (AP-2)
- phosphorylated on Tyr by EGFR
Structure:
- contains 1 EF-hand domain
- contains 3 EH domains
Compartment:
- cell membrane, nucleus
- localized to plasma membrane coated pits
General
Ca+2 binding protein
membrane protein
phosphoprotein
Properties
SIZE: MW = 94 kD
entity length = 864 aa
COMPARTMENT: cell nucleus
MOTIF: EH 1 {15-104}
MOTIF: Tyr phosphorylation site {Y74}
Ser phosphorylation site {S108}
EH 2 {127-215}
MOTIF: EF hand
SITE: 159-194
Ser phosphorylation site {S229}
Ser phosphorylation site {S241}
Ser phosphorylation site {S244}
Ser phosphorylation site {S250}
Ser phosphorylation site {S255}
EH 3 {275-365}
MOTIF: Ser phosphorylation site {S355}
Thr phosphorylation site {T366}
repeat {618-835}
MOTIF: consensus repeat {618-620}
SEQUENCE-IS: DPF
consensus repeat {640-642}
SEQUENCE-IS: DPF
consensus repeat {645-647}
SEQUENCE-IS: DPF
consensus repeat {650-652}
SEQUENCE-IS: DPF
consensus repeat {656-658}
SEQUENCE-IS: DPF
consensus repeat {661-663}
SEQUENCE-IS: DPF
consensus repeat {667-669}
SEQUENCE-IS: DPF
consensus repeat {685-687}
SEQUENCE-IS: DPF
consensus repeat {690-692}
SEQUENCE-IS: DPF
consensus repeat {709-711}
SEQUENCE-IS: DPF
consensus repeat {728-730}
SEQUENCE-IS: DPF
proline-rich region
SITE: 750-816
MOTIF: proline residue (SEVERAL)
consensus repeat {754-756}
SEQUENCE-IS: DPF
Ser phosphorylation site {S793}
consensus repeat {806-808}
SEQUENCE-IS: DPF
consensus repeat {812-814}
SEQUENCE-IS: DPF
consensus repeat {833-835}
SEQUENCE-IS: DPF
Database Correlations
UniProt Q9UBC2
Pfam PF00036
References
UniProt :accession Q9UBC2