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epsin-1 (EPS-15-interacting protein 1, EH domain-binding mitotic phosphoprotein, EPN1)
Function:
1) binds to membranes enriched in phosphatidylinositol-4,5- biphosphate (PIP2)
2) modifies membrane curvature & facilitates formation of clathrin-coated invaginations
3) regulates receptor-mediated endocytosis
4) binds clathrin, ZBTB16/ZNF145 & ITSN1
5) binds ubiquitinated proteins
6) binds REPS2, EPS15, AP2A1, AP2A2
7) NPF repeat domain is involved in EPS15 binding
8) DPW repeat domain is involved in AP2A2 & clathrin binding
9) phosphorylated on Ser &/or Thr in mitotic cells
10) phosphorylation diminishes interaction with REPS2, AP-2 & membrane
11) depolarization of synaptosomes results in dephosphorylation
12) ubiquitinated
Structure:
1) belongs to the epsin family
2) contains 1 ENTH domain (epsin N-terminal homology domain)
- contains 2 UIM repeats (ubiquitin-interacting motif)
Compartment:
- cytoplasm, peripheral membrane, nucleus, clathrin-coated pit
- colocalizes with clathrin & AP-2 on the plasma membrane
- detected in presynaptic nerve terminals & in Golgi stacks
- may shuttle to the nucleus when associated with ZBTB16/ZNF145
Alternative splicing: named isoforms=3
General
other protein
Properties
SIZE: MW = 58 kD
entity length = 551 aa
COMPARTMENT: cytoplasm
cell nucleus
golgi
MOTIF: binding site
SITE: 8-8
FOR-BINDING-OF: phosphatidylinositol-4,5-phosphate
binding site
SITE: 11-11
FOR-BINDING-OF: phosphatidylinositol-4,5-phosphate
ENTH {12-144}
MOTIF: binding site
SITE: 25-25
FOR-BINDING-OF: phosphatidylinositol-4,5-phosphate
binding site
SITE: 30-30
FOR-BINDING-OF: phosphatidylinositol-4,5-phosphate
binding site
SITE: 63-63
FOR-BINDING-OF: phosphatidylinositol-4,5-phosphate
binding site
SITE: 73-73
FOR-BINDING-OF: phosphatidylinositol-4,5-phosphate
UIM {183-202}
UIM {208-227}
Pro Rich [ED]-P-W repeats
NAME: Pro Rich [ED]-P-W repeats
SITE: 242-548
MOTIF: proline residue (SEVERAL)
consensus repeat {249-251}
consensus repeat {269-271}
consensus repeat {281-283}
consensus repeat {294-296}
consensus repeat {307-309}
consensus repeat {324-326}
consensus repeat {342-344}
consensus repeat {352-354}
Ser phosphorylation site {S357}
FOR-PHOSPHORYLATION-BY: cyclin-dependent kinase-1
N-P-F repeats {477-549}
MOTIF: consensus repeat {477-479}
consensus repeat {493-495}
consensus repeat {547-549}
Database Correlations
OMIM 607262
UniProt Q9Y6I3
PFAM correlations
References
- UniProt :accession Q9Y6I3
- Protein Spotlight
The bubble's bend - Issue 42 of January 2004
http://www.expasy.org/spotlight/back_issues/sptlt042.shtml