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epigenetic transcriptional repression
- transcriptional repression through an epigenetic mechanism
- histone H3 Lys-9 methylation & trimethylation represent specific tags for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 &/or CBX5) proteins to methylated histones [1]
- histone N-methyltransferases methylating Lys-9 of histone H3 include:
- EHMT1, EHMT2, SETDB1, SETDB2
- histone N-methyltransferases that methylate monomethyl Lys9 of histone H3 include:
- SUV39H1, SUV39H2
- histone H3 Lys-9 trimethylation is also required to direct DNA methylation at pericentric repeats
- demethylation of histone H3 Lys-9 derepresses transcription
- histone demethylases demethylating histone H3 Lys-9 include:
- JMJD2C
- histone H3 Lys-27 methylation is a mark for epigenetic transcriptional repression [3]
- histone H4 Lys-20 methylation is enriched during mitosis & represents a specific tag for epigenetic transcriptional repression [2]
- histone N-methyltransferases methylating Lys-20 of histone H4 include:
- NSD1, SETD8, SUV420H1, SUV420H2
Related
epigenetic
General
epigenetic transcriptional regulation
transcriptional silencing
References
- UniProt :accession Q15047
- UniProt :accession Q9NQR1
- UniProt :accession Q9BZ95