epoxide hydrolase 1 (microsomal epoxide hydrolase, EPHX1, EPHX, EPOX)

Function: - biotransformation enzyme that catalyzes hydrolysis of arene & aliphatic epoxides to less reactive & more water soluble dihydrodiols by the trans addition of water cis-stilbene oxide + H₂O (+)-(1R,2R)-1,2-diphenylethane-1,2-diol Structure: belongs to the peptidase S33 family Compartment: microsome membrane Expression: found in liver Pathology: - genetic variation in EPHX1 may be associated with susceptibility to preeclampsia - defects in EPHX1 are a cause of familial hypercholanemia

Properties

SIZE: entity length = 455 aa MW = 53 kD COMPARTMENT: smooth endoplasmic reticulum MOTIF: transmembrane domain {2-20}

Database Correlations

OMIM correlations MORBIDMAP 132810 UniProt P07099 PFAM correlations Entrez Gene 2052 ENZYME 3.3.2.9

References

UniProt :accession P07099