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eph family receptor
Function:
- role in:
a) embryonic patterning
b) neural development (eg. neural crest cell migration)
c) synaptic plasticity (axon pathfinding)/learning & memory
d) angiogenesis
- signalling between eph receptors & eph ligands is bidirectional
- binding of eph ligand to eph receptor induces receptor dimerization & trans-phosphorylation of cytoplasmic kinase domains
- phosphorylated Tyr serve as docking sites for proteins including ras-GTPase activating protein, src & abl family proteins, phospholipase C-gamma, PI-3-kinase & adaptor proteins SLAP, grb2, grb10 & nck
Structure:
- PDZ binding motif binds PDZ domain containing proteins including AF6, pick 1, syntenin, grip 1 & grip 2
Specific
ephA receptor
ephB receptor
General
adhesion receptor
tyrosine kinase receptor (RTK)
Properties
COMPARTMENT: plasma membrane
STATE: active state
MOTIF: ligand-binding site
cysteine-rich region
fibronectin type III domain or F3 module (2)
transmembrane domain
membrane region
kinase domain
MOTIF: ATP-binding site
NAME: ATP-binding site
Tyr phosphorylation site
binding site
FOR-BINDING-OF: ephrin
MOTIF: immunoglobulin superfamily domain
PDZ recognition motif
NAME: PDZ recognition motif
SITE: C-TERMINUS
FOR-BINDING-VIA: PDZ domain
References
- Eph Nomenclature Committee. Cell 90:403-4 1997
- Cheng N, Brantley DM, Chen J.
The ephrins and Eph receptors in angiogenesis.
Cytokine Growth Factor Rev. 2002 Feb;13(1):75-85. Review.
PMID: 11750881