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ephrin type-B receptor 1; tyrosine-protein kinase receptor EPH-2; NET; HEK6; ELK (EPHB1, EPHT2, NET)
Function:
- receptor for members of the ephrin-B family, binds to ephrin-B1, ephrin-B2 & ephrin-B3
- may be involved in cell-cell interactions in the nervous system
- ligand-activated interacts with GRB2, GRB10 & NCK through their respective SH2 domains
- GRB10 SH2 domain binds EPHB1 through Tyr-928, while GRB2 binds residues within the catalytic domain
- NCK SH2 domain binds EPHB1 through Tyr-594
- interacts with PRKCABP (putative)
Structure:
- belongs to the protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
- contains 2 fibronectin F3 modules
- contains 1 protein kinase domain
- contains 1 SAM (sterile alpha motif) domain
Compartment: membrane
Alternative splicing: named isoforms=4
Expression: preferentially expressed in brain
General
ephB receptor
glycoprotein
Properties
SIZE: entity length = 984 aa
MW = 110 kD
COMPARTMENT: cellular membrane
STATE: active state
MOTIF: signal sequence {1-17}
cysteine-rich region {183-319}
fibronectin type III domain or F3 module {323-424}
MOTIF: N-glycosylation site {N334}
N-glycosylation site {N426}
fibronectin type III domain or F3 module {430-525}
MOTIF: N-glycosylation site {N480}
transmembrane domain {541-563}
kinase domain
SITE: 619-882
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 625-633
ATP-binding site
NAME: ATP-binding site
SITE: 651-651
aspartate residue {D744}
sterile alpha motif
NAME: sterile alpha motif
SITE: 911-975
MOTIF: Tyr phosphorylation site {Y928}
Ser phosphorylation site {S968}
PDZ recognition motif
NAME: PDZ recognition motif
SITE: 982-984
FOR-BINDING-VIA: PDZ domain
Database Correlations
OMIM 600600
UniProt P54762
PFAM correlations
Entrez Gene 2047
Kegg hsa:2047
ENZYME 2.7.10.1
References
- UniProt :accession P54762
- Eph Nomenclature Committee. Cell 90:403-4 1997