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Ephrin type-A receptor 7; ephA7 receptor; tyrosine-protein kinase receptor EHK-3; EPH homology kinase 3; receptor protein-tyrosine kinase HEK11 (EPHA7, EHK3, HEK11, CEK11, MDK1, EBK)
Function:
- receptor for members of the ephrin-A family
- binds to ephrin-A1, -A2, -A3, -A4 & -A5
- interacts with PRKCABP & GRIP1 (putative)
Structure:
- belongs to the protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
- contains 2 fibronectin F3 modules
- contains 1 protein kinase domain
- contains 1 SAM (sterile alpha motif) domain
Compartment: membrane
Alternative splicing: named isoforms=3
Expression: widely expressed
General
ephA receptor
Properties
SIZE: entity length = 998 aa
MW = 112 kD
COMPARTMENT: cellular membrane
STATE: active state
MOTIF: signal sequence {1-24}
cysteine-rich region {192-328}
fibronectin type III domain or F3 module {331-433}
MOTIF: N-glycosylation site {N343}
N-glycosylation site {N410}
fibronectin type III domain or F3 module {443-535}
transmembrane domain {557-577}
Tyr phosphorylation site {Y608}
Tyr phosphorylation site {Y614}
kinase domain
SITE: 633-894
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 639-647
ATP-binding site
NAME: ATP-binding site
SITE: 665-665
aspartate residue {D758}
Tyr phosphorylation site {Y791}
sterile alpha motif
NAME: sterile alpha motif
SITE: 923-987
MOTIF: Tyr phosphorylation site {Y940}
PDZ recognition motif
NAME: PDZ recognition motif
SITE: 996-998
FOR-BINDING-VIA: PDZ domain
Database Correlations
OMIM 602190
UniProt Q15375
PFAM correlations
Entrez Gene 2045
Kegg hsa:2045
References
- Eph Nomenclature Committee. Cell 90:403-4 1997
- UniProt :accession Q15375