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ephrin type-A receptor 3; ephA3 receptor; tyrosine-protein kinase receptor ETK1; HEK; HEK4; tyrosine-protein kinase TYRO4 (EPHA3, ETK, ETK1, HEK, TYRO4)
Function:
1) receptor for members of the ephrin-A family
2) binds to ephrin-A2, ephrin-A3, ephrin-A4 ephrin-A5
3) lymphoid function (putative)
Structure:
- belongs to the protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
- contains 2 fibronectin F3 modules
- contains 1 protein kinase domain
- contains 1 SAM (sterile alpha motif) domain
Compartment:
- isoform 1: cell membrane
- isoform 2: secreted
Alternative splicing: named isoforms=2
Expression: widely expressed, highest level in placenta
Pathology: defects in EPHA3 may be a cause of colorectal cancer
Note:
- may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
General
ephA receptor
Properties
SIZE: MW = 110 kD
entity length = 983 aa
COMPARTMENT: plasma membrane
STATE: active state
MOTIF: signal sequence {1-20}
cysteine-rich region {189-322}
MOTIF: N-glycosylation site {N232}
fibronectin type III domain or F3 module {325-429}
MOTIF: N-glycosylation site {N337}
N-glycosylation site {N391}
N-glycosylation site {N404}
fibronectin type III domain or F3 module {437-528}
MOTIF: N-glycosylation site {N493}
transmembrane domain {542-565}
Tyr phosphorylation site {Y596}
Tyr phosphorylation site {Y602}
kinase domain
SITE: 621-882
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 627-635
ATP-binding site
NAME: ATP-binding site
SITE: 653-653
aspartate residue {D746}
Tyr phosphorylation site {Y779}
sterile alpha motif
NAME: sterile alpha motif
SITE: 911-975
Database Correlations
OMIM correlations
UniProt P29320
PFAM correlations
Entrez Gene 2042
Kegg hsa:2042
ENZYME 2.7.10.1
References
- Eph Nomenclature Committee. Cell 90:403-4 1997
- Entrez Gene :accession 2042