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SWI/SNF-like EPAFa chromatin-remodeling complex
Function:
- chromatin remodeling
Structure:
- subunits: SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCC1/BAF155, SMARCC2/BAF170, BAF250A & MLLT1/ENL
General
SWI/SNF chromatin remodeling complex
Properties
COMPARTMENT: cell nucleus
SUBUNITS: transcription activator BRG1
COMPARTMENT: cell nucleus
MOTIF: SS18L1/CREST interaction {1-282}
MOTIF: Thr phosphorylation site {T11}
HSA {460-532}
lysine-rich region {578-588}
MOTIF: lysine residue (SEVERAL)
Thr phosphorylation site {T609}
Ser phosphorylation site {S610}
Ser phosphorylation site {S613}
Ser phosphorylation site {S655}
Ser phosphorylation site {S657}
Ser phosphorylation site {S660}
Ser phosphorylation site {S662}
glutamate-rich region {663-672}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S695}
Ser phosphorylation site {S699}
Ser phosphorylation site {S721}
helicase
NAME: helicase
SITE: 766-931
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 779-786
DEAD/H box
NAME: DEAD/H box
SITE: 881-884
Helicase C-terminal {1084-1246}
glutamate-rich region {1360-1364}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S1382}
Ser phosphorylation site {S1452}
bromodomain {1477-1547}
MOTIF: peptide motif {1539-1540}
Ser phosphorylation site {S1570}
glutamate-rich region {1571-1584}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S1575}
Ser phosphorylation site {S1586}
Ser phosphorylation site {S1627}
Ser phosphorylation site {S1631}
Ser phosphorylation site {S1640}
Ser phosphorylation site {S1642}
Ser phosphorylation site {S1644}
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
COMPARTMENT: cell nucleus
MOTIF: binding site
SITE: 106-183
FOR-BINDING-OF: deoxyribonucleic acid (DNA)
MOTIF: Ser phosphorylation site {S129}
binding site
SITE: 183-243
FOR-BINDING-OF: HIV-1 INTEGRASE
tandem repeats {186-319}
MOTIF: consensus repeat {186-245}
binding site
SITE: 186-245
FOR-BINDING-OF: myc protein family
consensus repeat {259-319}
PPP1R15A interaction {304-318}
actin-like protein 6A
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S233}
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 5-65
MOTIF: proline residue (SEVERAL)
HMG box
SITE: 66-134
coiled coil {220-319}
MOTIF: Ser phosphorylation site {S265}
glutamate-rich region {320-411}
MOTIF: glutamate residue (SEVERAL)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
COMPARTMENT: cell nucleus
MOTIF: multiple interactions {43-167}
MOTIF: lysine-rich region {124-127}
MOTIF: lysine residue (SEVERAL)
SMARCC1/SMARCC2 interaction {168-474}
domain {180-515}
MOTIF: SWIB {291-390}
coiled coil {412-440}
SWI/SNF complex subunit SMARCC1
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S301}
Ser phosphorylation site {S310}
Ser phosphorylation site {S319}
Ser phosphorylation site {S328}
proline-rich region
SITE: 329-336
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S330}
Thr phosphorylation site {T335}
Thr phosphorylation site {T337}
Ser phosphorylation site {S339}
Ser phosphorylation site {S357}
SWIRM {449-546}
Ser phosphorylation site {S573}
SANT {618-669}
glutamate-rich region {769-863}
MOTIF: glutamate residue (SEVERAL)
alanine-rich region {867-878}
MOTIF: alanine residue (SEVERAL)
coiled coil {914-946}
proline-rich region
SITE: 977-1105
MOTIF: proline residue (SEVERAL)
SWI/SNF complex subunit SMARCC2
COMPARTMENT: cell nucleus
MOTIF: glutamate-rich region {186-189}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S283}
Ser phosphorylation site {S286}
Tyr phosphorylation site {Y296}
Ser phosphorylation site {S302}
Ser phosphorylation site {S304}
Ser phosphorylation site {S306}
Thr phosphorylation site {T322}
Ser phosphorylation site {S347}
SWIRM {424-521}
SANT {596-647}
glutamate-rich region {747-855}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S806}
Ser phosphorylation site {S810}
alanine-rich region {861-870}
MOTIF: alanine residue (SEVERAL)
coiled coil {907-934}
glutamine-rich region {956-960}
MOTIF: glutamine residue (SEVERAL)
proline-rich region
SITE: 961-1213
MOTIF: proline residue (SEVERAL)
AT-rich interactive domain-containing protein 1A
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S79}
Ser phosphorylation site {S233}
Thr phosphorylation site {T286}
LXXLL {295-299}
Ser phosphorylation site {S363}
Ser phosphorylation site {S382}
glutamine-rich region {479-482}
MOTIF: glutamine residue (SEVERAL)
glutamine-rich region {561-567}
MOTIF: glutamine residue (SEVERAL)
Ser phosphorylation site {S604}
Ser phosphorylation site {S696}
Ser phosphorylation site {S698}
Ser phosphorylation site {S702}
Ser phosphorylation site {S764}
Ser phosphorylation site {S772}
serine-rich region {998-1001}
MOTIF: serine residue (SEVERAL)
ARID {1017-1108}
Ser phosphorylation site {S1184}
glutamine-rich region {1327-1404}
MOTIF: glutamine residue (SEVERAL)
LXXLL {1709-1713}
Ser phosphorylation site {S1755}
Ser phosphorylation site {S1944}
LXXLL {1967-1971}
LXXLL {2085-2089}
protein ENL
COMPARTMENT: cell nucleus
MOTIF: YEATS {8-112}
Ser phosphorylation site {S155}
Ser phosphorylation site {S209}
proline-rich region
SITE: 272-280
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S292}
Ser phosphorylation site {S296}
Ser phosphorylation site {S315}
serine-rich region {319-325}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S359}
Ser phosphorylation site {S361}
Ser phosphorylation site {S366}
serine-rich region {374-389}
MOTIF: serine residue (SEVERAL)
proline-rich region
SITE: 457-460
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 463-466
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S475}
References
UniProt :accession O14497
Components
actin-like protein 6A; 53 kD BRG1-associated factor A; actin-related protein Baf53a; ArpNbeta; BRG1-associated factor 53A; BAF53A; INO80 complex subunit K (ACTL6A, BAF53, BAF53A, INO80K)
AT-rich interactive domain-containing protein 1A; ARID domain-containing protein 1A; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1; SWI/SNF complex protein p270; B120; SWI-like protein; Osa homolog 1; hOSA1; hELD; BRG1-associated factor 250; BAF250; BRG1-associated factor 250a; BAF250A (ARID1A, BAF250, BAF250A, C1orf4, OSA1, SMARCF1)
ENL (eleven-nineteen leukemia) proto oncogene protein; protein ENL; YEATS domain-containing protein 1 (MLLT1 ENL LTG19 YEATS1)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; transcription activator BRG1; ATP-dependent helicase SMARCA4; SNF2-beta; protein BRG-1; mitotic growth & transcription activator; protein brahma homolog 1; BRG1-associated factor 190A; BAF190A (SMARCA4, BAF190A, BRG1, SNF2B, SNF2L4)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; integrase interactor 1 protein; SNF5 homolog; hSNF5; BRG1-associated factor 47; BAF47 (SMARCB1, BAF47, INI1, SNF5L1)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1; SWI/SNF complex subunit SMARCC1; SWI/SNF complex 155 kD subunit; BRG1-associated factor 155; BAF155 (SMARCC1, BAF155)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2; SWI/SNF complex subunit SMARCC2; SWI/SNF complex 170 kD subunit; BRG1-associated factor 170; BAF170 (SMARCC2, BAF170)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1; SWI/SNF complex 60 kD subunit; 60 kD BRG-1/Brm-associated factor subunit A; BRG1-associated factor 60A; BAF60A (SMARCD1, BAF60A)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1; BRG1-associated factor 57; BAF57 (SMARCE1, BAF57)