eosinophil cationic protein (ribonuclease 3, RNase3, ECP)

Function: - cytotoxin & helminth toxin - antibacterial activity - low-efficiency ribonuclease activity - wide variety of biological activities Structure: - belongs to the pancreatic ribonuclease family Compartment: matrix of eosinophil's large specific granule Pathology: - induces neurotoxic effect known as the Gordon phenomenon Laboratory: - eosinophil cationic protein in nasal fluid - eosinophil cationic protein in serum

General

endoribonuclease glycoprotein

Properties

SIZE: MW = 18 kD entity length = 160 aa MOTIF: signal sequence {1-27} histidine residue {H42} cysteine residue {C50} MODIFICATION: cysteine residue {C110} cysteine residue {C64} MODIFICATION: cysteine residue {C123} Substrate binding {65-69} cysteine residue {C82} MODIFICATION: cysteine residue {C138} N-glycosylation site {N84} cysteine residue {C89} MODIFICATION: cysteine residue {C98} N-glycosylation site {N92} cysteine residue {C98} MODIFICATION: cysteine residue {C89} cysteine residue {C110} MODIFICATION: cysteine residue {C50} N-glycosylation site {N119} cysteine residue {C123} MODIFICATION: cysteine residue {C64} cysteine residue {C138} MODIFICATION: cysteine residue {C82} histidine residue {H155}

Database Correlations

OMIM 131398 UniProt P12724

References

UniProt :accession P12724