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enterovirus 71; enterovirus A71 (EV71, EV-A71)
Pathology:
- common cause of
- hand, foot, & mouth disease
- herpangina
- viral meningitis
- morbidity & mortality from EV71 infection is low
Epidemiology:
- Asia-Pacific region
- outbreak of enterovirus A71 in Colorado (2018), 34 children with neurologic disease
- cases of meningitis (12), encephalitis (9), flaccid myelitis (3), ataxia (7), myoclonus (6)
Laboratory:
- Enterovirus 71 RNA
Management:
- Enterovirus 71 vaccine effective [1]
Related
enterovirus 71 vaccine
General
enterovirus
Properties
KINGDOM: virus
GENOME-TYPE: RNA
SINGLE-STRANDED
POSITIVE-STRAND
GENOME-SIZE: 7.2-8.4 kB
ENVELOPE: NONE
CAPSID-SYMMETRY: ICOSAHEDRAL
References
- Zhu FC et al
Efficacy, safety, and immunology of an inactivated alum-adjuvant
enterovirus 71 vaccine in children in China: a multicentre,
randomised, double-blind, placebo-controlled, phase 3 trial.
The Lancet. May 29, 2013
PMID: 23726161
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)61049-1/abstract
- Messacar K, Burakoff A, Nix WA, et al.
Notes from the Field: Enterovirus A71 Neurologic Disease in Children
- Colorado, 2018.
MMWR Morb Mortal Wkly Rep 2018;67:1017-1081
https://www.cdc.gov/mmwr/volumes/67/wr/mm6736a5.htm