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ensitrelvir
Indications:
- investigational treatment of outpatient Covid-19
- may reduce long Covid-19 symptoms
- non-inferior to Paxlovid (nirmatrelvir/ritonavir) for improving SARS CoV-2 viral clearance at 5 days [3]
* reduces symptoms of mild-moderate Covid-19 by ~1 day
* reduces number of days patients test positive for Covid-19
Dosage:
- 125 mg superior to 250 mg PO QD within 5 days of symptom onset
* median time to resolution of Covid-10 symptoms 24 hours sooner than placebo
* SARS-CoV2 viral titers negative within a median of 36 hours vs 65 hours with placebo
* 87% reduction of infectious SARS-Cov2 at day 4
Adverse effects:
- was well tolerated, no serious treatment-related adverse events or deaths
- most common treatment-related adverse events
- temporary decreases in HDL cholesterol increased serum triglycerides
Mechanism of action:
- 3C-like protease inhibitor that targets SARS-Cov2
- maintains activity across different variants including Omicron
General
antiviral agent
Database Correlations
PUBCHEM correlations
References
- Hein I
Investigational Oral Antiviral Shows Promise in COVID Outpatients.
Exploratory analyses also point to possible reduction in long COVID symptoms.
MedPage Today February 22, 2023
https://www.medpagetoday.com/meetingcoverage/croi/103222
- Lenharo M
COVID pill is first to cut short positive-test time after infection
Nature News 2023. March 3.
https://www.nature.com/articles/d41586-023-00548-6
- Schilling WHK, Jittamala P, Wongnak P, et al.
Antiviral efficacy of oral ensitrelvir versus oral ritonavir-boosted
nirmatrelvir in COVID-19 (PLATCOV): an open-label, phase 2, randomised,
controlled, adaptive trial.
Lancet Infect Dis. 2025 Oct 10:S1473-3099(25)00482-7.
PMID: 41082886 Free article
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00482-7/fulltext