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enoxacin (Penetrex)
Tradename: Penetrex.
Indications:
- bacterial infections due to susceptible organisms
- urogenital infection
- gonorrhea
- chancroid
- proctitis [3]
Dosage: 200-400 PO BID.
Tabs: 200, 400 mg.
Antimicrobial activity:
Gram positive
- Streptococcus pneumonia (+/-)
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis
Gram negative
- Neisseria gonorrhoeae
- Haemophilus influenzae
- Escherichia coli
- Klebsiella species
- Enterobacter species
- Proteus vulgaris
- Acinetobacter species (+/-)
- Pseudomonas aeruginosa
Drug interactions:
-> enoxacin inhibits cyt P450 1A2
-> may increase levels of drugs metabolized by cyt P450 1A2
Interactions
drug interactions
drug adverse effects of fluoroquinolones
Related
cytochrome p450 1A2 (cytochrome P3-450, phenacetin deethylase, cytochrome p450-4, CYP1A2)
General
fluoroquinolone
Properties
INHIBITS: DNA gyrase
MISC-INFO: elimination route LIVER
KIDNEY
pregnancy-category C
safety in lactation ?
Database Correlations
PUBCHEM cid=3229
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Sanford Guide to antimicrobial therapy 1997
- Deprecated Reference