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enolase (2-phospho-D-glycerate hydrolase)
Structure:
- enolase is a dimer of any 2 of 3 peptides, alpha, beta & gamma
Expression:
- alpha/alpha homodimer is expressed in embryo & in most adult tissues
- alpha/beta heterodimer & beta/beta homodimer are found in striated muscle
- alpha/gamma heterodimer & the gamma/gamma homodimer are found in neurons
Interactions
molecular events
Related
gluconeogenesis
glycolytic pathway (glycolysis, Embden Myerhof pathway)
Specific
enolase alpha, lung specific (ENO1B)
enolase-1, alpha enolase or phosphopyruvate hydratase
enolase-2; gamma-enolase; neuron specific enolase (ENO2)
enolase-3 (ENO3, beta-enolase)
Enolase-phosphatase E1 (EC 3.1.3.77, 2,3-diketo-5-methylthio-1- phosphopentane phosphatase, MASA homolog) (ENOPH1 MASA MSTP145)
General
glycolytic enzyme
hydro-lyase, hydratase or dehydratase
oligomerizing protein
Properties
CONFIGURATION: dimer
COMPARTMENT: cytoplasm
MOTIF: active site
Mg+2-binding site
Database Correlations
OMIM 172430
ENZYME 4.2.1.11
References
- OMIM :accession 172430
- Clinical Guide to Laboratory Tests, 3rd edition, NW Tietz
ed, WB Saunders, Philadelphia, 1995
- UniProt :accession P06733, P09104