enhancer of mRNA-decapping protein 4 (human enhancer of decapping large subunit, Hedls, autoantigen Ge-1, autoantigen RCD-8, EDC4, HEDLS)

Function: 1) role in mRNA degradation 2) role in mRNA decapping 3) component of a mRNA decapping complex which functions in decapping of ARE-containing mRNAs 4) promotes complex formation between DCP1A & DCP2 5) enhances catalytic activity of DCP2 (in vitro) 6) component of a complex consisting of DCP1B, EDC3, EDC4 & DDX6 (not clear if different from mRNA decapping complex) 7) interacts with DCP2 8) phosphorylated upon DNA damage, probably by ATM or ATR Structure: contains 4 WD repeats Alternative splicing: named isoforms=2

General

phosphoprotein protein subunit WD repeat protein family

Properties

SIZE: MW = 152 kD entity length = 1401 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: WD repeat {174-214} WD repeat {230-277} WD repeat {295-334} WD repeat {342-393} serine-rich region {602-676} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S729} Ser phosphorylation site {S741} Ser phosphorylation site {S844} Ser phosphorylation site {S875} Ser phosphorylation site {S879} Ser phosphorylation site {S887} nuclear localization {913-934} coiled coil {954-1025} Ser phosphorylation site {S1067} Thr phosphorylation site {T1072}

Database Correlations

OMIM 606030 UniProt Q6P2E9 Pfam PF00400

References

UniProt :accession Q6P2E9