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endothelin receptor
Receptor types Et-a & ET-b? [3]
Interactions
molecular events
Related
endothelin
Specific
endothelin B receptor; ET-B; endothelin receptor non-selective type (EDNRB, ETRB)
endothelin-1 receptor; endothelin A receptor; hET-AR; ETA-R; ET-A (EDNRA, ETA, ETRA)
General
G-protein coupled receptor; serpentine receptor
Properties
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {N-TERMINAL}
N-glycosylation site {N-TERMINAL}
ligand-binding site
transmembrane domain {TM1}
transmembrane domain {TM2}
transmembrane domain {TM3}
transmembrane domain {TM4}
transmembrane domain {TM5}
transmembrane domain {TM6}
transmembrane domain {TM7}
transmembrane domain (7)
guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
binding site
SITE: C-TERMINAL-CYS
EFFECTOR-BOUND: palmitate
BOUND-VIA: carboxylate
S/T phosphorylation site {CYTOPLASMIC-TAIL}
cysteine residue {CYTOPLASMIC-TAIL}
MODIFICATION: palmitate
COMPARTMENT: membrane
cytoplasmic domain {C-TERMINAL}
S/T phosphorylation site {C-TERMINAL}
References
- MacCumber MW, Ross CA, Snyder SH.
Endothelin in brain: receptors, mitogenesis, and biosynthesis
in glial cells.
Proc Natl Acad Sci U S A. 1990 Mar;87(6):2359-63.
PMID: 2156267
- Miller RC, Pelton JT, Huggins JP.
Endothelins-from receptors to medicine.
Trends Pharmacol Sci. 1993 Feb;14(2):54-60. Review.
PMID: 8480375
- prosite :accession PS00237