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endothelin
A family of vasoconstricting peptides.
Interactions
molecular events
Related
endothelin receptor
Specific
endothelin-1; preproendothelin-1; PPET1; contains: endothelin-1; ET-1; big endothelin-1 (EDN1)
endothelin-2; ET-2; preproendothelin-2; PPET2 (EDN2)
endothelin-3; ET-3; preproendothelin-3; PPET3 (EDN3)
General
secreted peptide
vasoconstrictor
Properties
COMPARTMENT: extracellular compartment
MOTIF: cysteine-rich region
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+14}
cysteine residue {X+2}
MODIFICATION: cysteine residue {X+10}
cysteine residue {X+10}
MODIFICATION: cysteine residue {X+2}
cysteine residue {X+14}
MODIFICATION: cysteine residue {X+0}
References
MacCumber et al Proc Natl Acad Sci USA 1990 Mar;87(6):
2359-63