endophilin-A3; EEN-B2; endophilin-3; SH3 domain protein 2C; SH3 domain-containing GRB2-like protein 3 (SH3GL3, CNSA3, SH3D2C)

Function: - implicated in endocytosis - may recruit other proteins to membranes with high curvature (putative) - interacts with ARC (putative) - interacts with DNM1, SGIP1 & SYNJ1 - interacts with DYDC1 Structure: - an N-terminal amphipathic helix, the BAR domain & a 2nd amphipathic helix inserted into helix 1 of the BAR domain induce membrane curvature & bind curved membranes - belongs to the endophilin family - contains 1 BAR domain - contains 1 SH3 domain Compartment: - cytoplasm (putative) - early endosome membrane - peripheral membrane (putative) - associated with postsynaptic endosomes in hippocampal neurons - associated with presynaptic endosomes in olfactory neurons (putative) Alternative splicing: named isoforms=4 Expression: brain & testis Pathology: - interacts with the huntingtin exon 1 protein (HDEX1P) containing a glutamine repeat in the pathological range & promotes formation of insoluble polyglutamine-containing aggregates in vivo

General

phosphoprotein SH3-containing GRB2-like protein

Properties

SIZE: entity length = 347 aa MW = 39 kD COMPARTMENT: cytoplasm MOTIF: binding site SITE: 1-21 FOR-BINDING-OF: membrane BAR {18-249} MOTIF: dimerization {60-87} coiled coil {181-201} ARC interaction {218-254} Ser phosphorylation site {S265} src homology 3 [SH3] domain SITE: 285-344

Database Correlations

OMIM 603362 UniProt Q99963 PFAM correlations Entrez Gene 6457 Kegg hsa:6457

References

UniProt :accession Q99963