Search
endogenous retroviral REC protein
Endogenous retroviral proteins may have kept, lost or modified their original function during evolution.
Function:
- Rec interacts with an RNA element (RcRE) present in viral 3'LTR & recruits the cellular nuclear export machinery
- this permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts
- associates with XPO1 & with ZNF145
Structure:
- forms homodimers, homotrimers, & homotetramers via a C-terminal domain
- despite functional similarity, Rec shares almost no sequence homology with HIV-1 Rev & HTLV-1 Rex
Compartment:
- nucleus, nucleolus
- shuttles between the nucleus & cytoplasm
- when in the nucleus, resides in the nucleolus
Specific
HERV-K 10p14 provirus Rec protein
HERV-K 11q22.1 provirus Rec protein
HERV-K 12q14.1 provirus Rec protein
HERV-K 19p13.11 provirus Rec protein (HERV-K113 Rec protein)
HERV-K 19q12 provirus Rec protein (HERV-K(C19) Rec protein)
HERV-K 5q13.3 provirus Rec protein (HERV-K104 Rec protein)
HERV-K 6q14.1 provirus Rec protein (HERV-K109 Rec protein, HERV-K(C6) Rec protein)
HERV-K 7q22.1 provirus Rec protein; HERV-K (HML-2.HOM) Rec protein; HERV-K108 Rec protein; HERV-K(C7) Rec protein; central open reading frame; cORF; c-orf; Rev-like protein; Rev/Rex homolog; K-Rev (ERVK6, ERVK-6)
HERV-K 8p23.1 provirus Rec protein (HERV-K115 Rec protein)
General
endogenous retroviral protein