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darifenacin (Enablex)
Tradenames: Enablex
Indications:
- overactive bladder
- urinary frequency, urinary urgency
Contraindications:
- use caution in patients with
a) narrow-angle glaucoma
b) gastroparesis & diminished peristalsis
c) obstructive uropathy
d) severe hepatic insufficiency
Dosage: 7.5-15 mg PO QD (no dose adjustment in the elderly) [4]
Adverse effects:
1) less drowsiness & dizziness than other anticholinergics
2) constipation (14%) [4]
3) xerostomia
4) visual impairment
Mechanism of action:
1) muscarinic M3 receptor antagonist
2) allegedly more selective for the muscarinc M3 receptor than other agents
Interactions
drug interactions
drug adverse effects of parasympatholytics
General
urinary antispasmodic
Database Correlations
PUBCHEM correlations
References
- Prescriber's Letter 11(9): 2004
Detail-Document#: 200910
(subscription needed) http://www.prescribersletter.com
- Prescriber's Letter 12(2): 2005
Antimuscarinic Medications for Overactive Bladder
Detail-Document#: 210209
(subscription needed) http://www.prescribersletter.com
- http://www.Sanctura.com
- Erdem M & Chu FM
Management of overactive bladder and urge urinary incontinence
in the elderly patient.
Am J Med 2006;119(3A):295