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emtricitabine/tenofovir (Truvada, TDF/FTC, Descovy)

Tradenames: - Truvada (Generic FDA-approved June 2017) [7] - Descovy emtricitabine 200 mg + tenofovir alafenamide Indications: - HIV-1 infection - pre-exposure prophylaxis a) up to 75% effective b) not-effective in women [4] Dosage: QD dosing Tabs: - Truvada: emtricitabine (FTC) 200 mg, tenofovir 300 mg QD - Descovy: emtricitabine 200 mg, tenofovir alafenamide QD [8] Storage: - store in orginal container - original container has a desiccant [6] Mechanism of action: 1) combination anti-retroviral agent 2) injected tenofovir 22 mg/kg/emtricitabine 20 mg/kg prevented HIV infection in rhesus monkeys Notes: Manufacturer: Gilead Sciences

General

antiretroviral combination

Database Correlations

PUBCHEM cid=5282497

References

  1. Prescriber's Letter 12(2): 2005 New Drugs Approved by the FDA in 2004 Detail-Document#: 210216 (subscription needed) http://www.prescribersletter.com
  2. Prescriber's Letter 13(5): 2006 Truvada (Emtricitabine/Tenofovir) and HIV prevention Detail-Document#: 220508 (subscription needed) http://www.prescribersletter.com
  3. Grant RM et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med 2010 Nov 23; PMID: 21091279 http://dx.doi.org/10.1056/NEJMoa1011205 - Michael NL. Oral preexposure prophylaxis for HIV - Another arrow in the quiver? N Engl J Med 2010 Nov 23; PMID: 21091280 http://dx.doi.org/10.1056/NEJMe1012929 - Prescriber's Letter 18(1): 2011 Truvada for Pre-Exposure Prophylaxis of HIV Infection Detail-Document#: 270106 (subscription needed) http://www.prescribersletter.com
  4. FHI statement on the FEM-PrEP HIV prevention study [press release]. Durham, NC: Family Health International; Apr 18 , 2011 http://www.fhi.org/en/AboutFHI/Media/Releases/FEM-PrEP_statement041811.htm - Perrone Matthew FDA panel backs first pill to block HIV infection Associated Press, May 10, 2012 http://news.yahoo.com/fda-panel-backs-first-pill-block-hiv-infection-225920976--finance.html
  5. FDA News Release: July 16, 2012 FDA approves first drug for reducing the risk of sexually acquired HIV infection http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm312210.htm
  6. Prescriber's Letter 21(6): 2014 Oral Meds to Keep in Original Containers Detail-Document#: 300622 (subscription needed) http://www.prescribersletter.com
  7. Lowes R FDA Approves First Generic Truvada in US Medscape - Jun 09, 2017. http://www.medscape.com/viewarticle/881368
  8. FDA News Release. Oct 3, 2019 FDA approves second drug to prevent HIV infection as part of ongoing efforts to end the HIV epidemic. https://www.fda.gov/news-events/press-announcements/fda-approves-second-drug-prevent-hiv-infection-part-ongoing-efforts-end-hiv-epidemic

Components

emtricitabine (Emtriva, FTC) tenofovir (TDF)