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emelin-1; elastin microfibril interface-located protein 1; elastin microfibril interfacer 1 (EMILIN1, EMI)
Function:
1) anchoring smooth muscle cells to elastic fibers
2) regulation of vessel assembly
3) cell adhesive capacity
4) interacts with EMILIN2
Structure:
- homotrimer associated through a moderately stable interaction of the C-terminal globular C1q domains, allowing nucleation of the triple helix & then a further quaternary assembly to higher-order polymers via intermolecular disulfide bonds
- contains 1 C1q domain
- contains 1 collagen-like domain
- contains 1 EMI domain
Compartment:
- secreted, extracellular matrix
- interface between amorphous elastin & microfibrils
Expression:
- distributed in tissues where resilience & elastic recoil are prominent
- expressed in small intestine, aorta, lung, uterus, appendix (adult) & in fetal spleen, kidney, lung, & heart > adult liver, ovary, colon, stomach, lymph node, spleen > adult heart, bladder, prostate, adrenal gland, mammary gland, placenta & kidney
- not expressed in adult skeletal muscle or brain
- deposition precedes the appearance of elastin, simultaneous with that of fibrillin 1
General
emilin; elastin microfibril interface located protein
Properties
SIZE: entity length = 1016 aa
MW = 107 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
EMI {56-131}
MOTIF: cysteine residue {C60}
MODIFICATION: cysteine residue {C121}
cysteine residue {C85}
MODIFICATION: cysteine residue {C92}
cysteine residue {C92}
MODIFICATION: cysteine residue {C85}
cysteine residue {C120}
MODIFICATION: cysteine residue {C129}
cysteine residue {C121}
MODIFICATION: cysteine residue {C60}
cysteine residue {C129}
MODIFICATION: cysteine residue {C120}
N-glycosylation site {N154}
coiled coil {216-256}
coiled coil {356-420}
MOTIF: N-glycosylation site {N415}
N-glycosylation site {N455}
N-glycosylation site {N561}
coiled coil {576-603}
N-glycosylation site {N658}
coiled coil {685-752}
N-glycosylation site {N766}
N-glycosylation site {N794}
Collagen-like {814-864}
MOTIF: coiled coil {835-857}
C1q {866-1016}
Database Correlations
OMIM 130660
UniProt Q9Y6C2
PFAM correlations
Entrez Gene 11117
Kegg hsa:11117
References
UniProt :accession Q9Y6C2