engulfment & cell motility protein 1 (CED-12 homolog, ELMO1, KIAA0281)

Function: 1) involved in cytoskeletal rearrangements required phagocytosis of apoptotic cells & cell motility 2) interacts with DOCK1 & CRK - part of a complex with DOCK1 & CRK 3) interacts directly with the SH3-domain of DOCK1 via its SH3-binding site 4) may enhance the guanine nucleotide exchange factor (GEF) activity of DOCK 5) part of a complex with DOCK1 & RAC1 6) phosphorylated by HCK Structure: - contains 1 ELMO domain - contains 1 PH domain Compartment: - cytoplasm, cell membrane - translocation to plasma membrane seems to be mediated by DOCK1 & CRK Alternative splicing: named isoforms=2 Expression: - widely expressed, higher expression in spleen, placenta

General

engulfment & cell motility protein (ELMO) phosphoprotein

Properties

SIZE: MW = 84 kD entity length = 727 aa COMPARTMENT: cytoplasm MOTIF: ELMO {318-491} PH domain {555-676} SH3-binding site NAME: SH3-binding site SITE: 707-714

Database Correlations

OMIM 606420 UniProt Q92556 Pfam PF04727

References

UniProt :accession Q92556