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elk1 proto-oncogene protein; ETS domain-containing protein Elk-1 (ELK1)
Function:
- stimulates transcription
- binds to purine-rich DNA sequences
- can form a ternary complex with the serum response factor & the ETS & SRF motifs of the fos serum response element
- interacts in its sumoylated form with PIAS2/PIASX which enhances its transcriptional activator activity
- sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation & diminished transactivator activity
- regulates nuclear retention
- on mitogenic stimulation, phosphorylated on C-terminal Ser & Thr by MAPK1
- Ser-383 & Ser-389 are the preferred sites for MAPK1
- in vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE & SRF
- phosphorylation leads to loss of sumoylation & restores transcriptional activator activity
Structure:
- belongs to the ETS family
- has 3 regions of homolgy with SAP-1 protein
- contains 1 ETS DNA-binding domain ETS domain located in the amino terminus of the protein
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression: lung & testis
Interactions
molecular events
Related
elk1 proto-oncogene
General
Ets family protein
phosphoprotein
Properties
SIZE: entity length = 428 aa
MW = 45 kD
COMPARTMENT: cell nucleus
MOTIF: ETS domain
NAME: ETS domain
SITE: 5-86
Ser phosphorylation site {S324}
Thr phosphorylation site {T336}
Ser phosphorylation site {S383}
Ser phosphorylation site {S389}
Ser phosphorylation site {S422}
Database Correlations
OMIM 311040
UniProt P19419
Pfam PF00178
Entrez Gene 2002
References
- Macleod K, Leprince D, Stehelin D.
The ets gene family.
Trends Biochem Sci. 1992 Jul;17(7):251-6. Review.
PMID: 1502727
- Sun H, Tonks NK, Bar-Sagi D.
Inhibition of Ras-induced DNA synthesis by expression of the
phosphatase MKP-1.
Science. 1994 Oct 14;266(5183):285-8.
PMID: 7939666 [p62TCF]
- Entrez Gene :accession 2002
- UniProt :accession P19419