eukaryotic initiation factor 2C1; protein argonaute-1; Argonaute1; hAgo1; argonaute RISC catalytic component 1; eukaryotic translation initiation factor 2C 1; eIF-2C 1; eIF2C 1; RNA-binding protein Q99 (AGO1, EIF2C1)

Function: - required for RNA-mediated gene silencing (RNAi) - binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), & represses translation of mRNAs complementary to them - lacks endonuclease activity & does not appear to cleave target mRNAs - also required for transcriptional gene silencing of promoter regions complementary to bound short antigene RNAs - interacts with DDB1, DDX5, DDX6, DHX30, DHX36, DDX47, DICER1, AGO₂, ELAVL1, HNRNPF, IGF2BP1, ILF3, IMP8, MATR3, MOV10, PABPC1, PRMT5, RBM4, SART3, TNRC6B, UPF1 & YBX1 - associates with polysomes & messenger ribonucleoproteins (mNRPs) - interacts with LIMD1, WTIP & AJUBA - interacts with APOBEC3F, APOBEC3G & APOBEC3H Structure: - belongs to the argonaute family, Ago subfamily - contains 1 PAZ domain - contains 1 Piwi domain Compartment: cytoplasm, P-body

Properties

SIZE: entity length = 857 aa MW = 97 kD COMPARTMENT: cytoplasm MOTIF: PAZ domain {226-346} Piwi domain {515-816}

Database Correlations

OMIM 606228 UniProt Q9UL18 PFAM correlations Entrez Gene 26523 Kegg hsa:26523

References

UniProt :accession Q9UL18