eukaryotic translation initiation factor 2A (eIF-2A, 65 kD eukaryotic translation initiation factor 2A, EIF2A)

Function: - functions in the early steps of protein synthesis of a mall number of specific mRNAs - acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits - in contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits (codon-dependent manner vs GTP-dependent for eIF-2 complex) Structure: - belongs to the WD repeat EIF2A family - contains 3 WD repeats Alternative splicing: named isoforms=2 Expression: - widely expressed - expressed at higher level in pancreas, heart, brain & placenta initially thought to constitute the ortholog of prokaryotic IF-2 (infB) protein

General

initiation factor phosphoprotein WD repeat protein family

Properties

SIZE: MW = 65 kD entity length = 585 aa COMPARTMENT: cytoplasm CELL: most cell types* ORGANISM: eukaryote* MOTIF: WD repeat {21-63} WD repeat {125-163} WD repeat {356-401} Ser phosphorylation site {S506} coiled coil {531-582}

References

UniProt :accession Q9BY44