eukaryotic initiation factor 2

Function: - eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP & initiator tRNA - this complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex - junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 & release of an eIF-2-GDP binary complex (putative) - in order for eIF-2 to recycle & catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (putative) - GTP-bound form supplies initiator methionyl-tRNA to ribosome Structure: - heterotrimer composed of an alpha, beta & gamma chain

Related

eukaryotic initiation factor 2-gamma; eIF2-gamma (EIF2S3) protein synthesis initiation

General

guanine nucleotide regulatory protein (GNRP) initiation factor multisubunit protein phosphoprotein

Properties

COMPARTMENT: cytoplasm CELL: most cell types* ORGANISM: eukaryote* MOTIF: guanine nucleotide-binding site SUBUNITS: eIF2-alpha MOTIF: Ser phosphorylation site guanine nucleotide-binding site eIF2-beta MOTIF: S/T phosphorylation site eIF2-gamma MOTIF: GTP-binding site

Components

eukaryotic initiation factor 2-alpha; eIF2-alpha (EIF2S1) eukaryotic initiation factor 2-beta; eIF2-beta (EIF2S2) eukaryotic initiation factor 2-gamma; eIF2-gamma (EIF2S3)