EP300-interacting inhibitor of differentiation 1 (EID-1, E1A-like inhibitor of differentiation 1, CREBBP/EP300 inhibitory protein 1, 21 kD pRb-associated protein, EID1, C15orf3, CRI1, RBP21, PNAS-22, PTD014)

Function: - interacts with RB1 & EP300 - acts as a repressor of MYOD1 transactivation - inhibits EP300 & CBP histone acetyltransferase activity - role in coupling cell cycle exit to transcriptional activation of genes required for cellular differentiation - candidate coinhibitory factor for NR0B2 - interacts via its LXCXE motif with pocket region of RB1 - interacts with EP300, NR0B2 & TRIM27 - ubiquitinated in U-2OS osteosarcoma cells & is rapidly degraded by proteasome as cells exit the cell cycle - inhibition of MYOD1 may be partly due to the ability of EID1 to bind & inhibit EP300 histone acetyltransferase activity Compartment: - nucleus, cytoplasm - may shuttle between nucleus & cytoplasm Alternative splicing: named isoforms=2 Expression: - widely expressed - expressed in heart, skeletal muscle, pancreas, brain, testis > placenta, peripheral blood leukocyte - barely detectable in lung - expression decreased with development in cardiac ventricular tissue, but remains high in adult atrial tissue - in human skeletal myocytes, expression decreased during myogenic differentiation (at protein level) - down-regulated in differentiating U937 leukemia cells Pathology: - weakly expressed in lung carcinoma A549 & various leukemia cell lines

Properties

SIZE: MW = 21 kD entity length = 187 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: NR0B2 interaction {54-120} LXCXE {178-182}

Database Correlations

OMIM 605894 UniProt Q9Y6B2

References

UniProt :accession Q9Y6B2