Contents

Search

epidermal growth factor receptor (EGFR) gene mutation

Indications: - eligibility for erlotinib in the treatment of non-small cell lung cancer [1] - useful if KRAS gene mutation is negative Procedure: - polymerase chain reaction with pyrosequencing - detects mutations in EGFR exons 18, 19, 20, & 21 - if EGFR gene mutation is negative, consider - ALK gene rearrangement - ROS1 gene mutation - if EGFR gene mutation is positive, consider - KRAS gene mutation Specimen: - specimen collected from fine needle aspiration - formalin fixation, parafin embedded - transport: room temperature or refrigerated - frozen is unacceptable

Related

epidermal growth factor receptor; receptor tyrosine-protein kinase ErbB-1 (EGFR, ERBB1, HER1)

General

gene mutation testing; gene mutation analysis

References

  1. FDA News Release: May 14, 2013 FDA approves first companion diagnostic to detect gene mutation associated with a type of lung cancer. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm352230.htm
  2. ARUP Consult: Lung Cancer deprecated reference