selenocysteine-specific elongation factor; elongation factor sec; eukaryotic elongation factor, selenocysteine-tRNA-specific (EEFSEC, SELB)

Function: - translation factor necessary for incorporation of selenocysteine into proteins - probably replaces EF-Tu for insertion of selenocysteine directed by the UGA codon - selB binds GTP & GDP Structure: - belongs to the GTP-binding elongation factor family selB subfamily Compartment: - cytoplasm (putative) - nucleus (potential)

General

selenoprotein translation elongation factor

Properties

SIZE: entity length = 596 aa MW = 65 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: GTP-binding site SITE: 14-21 GTP-binding site SITE: 92-96 GTP-binding site SITE: 146-150 nuclear translocation signal {547-553}

Database Correlations

OMIM 607695 UniProt P57772 PFAM correlations Entrez Gene 60678 Kegg hsa:60678

References

UniProt :accession P57772