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early endosome antigen 1; endosome-associated protein p162; zinc finger FYVE domain-containing protein 2 (EEA1, ZFYVE2)
Function:
- binds phospholipid vesicles containing phosphatidylinositol 3-phosphate & participates in endosomal trafficking
- homodimer
- binds STX6
- binds RAB5A, RAB5B, RAB5C & RAB22A that have been activated by GTP-binding
Structure:
- the FYVE-type Zn+2 finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes & penetrates bilayers
- the FYVE domain insertion into Ptdins(3)P-enriched membranes is substantially increased in acidic conditions
- contains 1 C2H2-type Zn+2 finger
- contains 1 FYVE-type Zn+2 finger
Compartment:
- cytoplasm
- early endosome membrane, peripheral membrane
Pathology:
- antibodies against EEA1 are found in sera from patients with subacute cutaneous lupus erythematosus & other autoimmune diseases
General
C2H2 type zinc finger protein
zinc finger FYVE domain-containing protein (ZFYVE)
Properties
SIZE: entity length = 1411 aa
MW = 162 kD
COMPARTMENT: cytoplasm
MOTIF: Zn finger C2H2-type
SITE: 41-64
EFFECTOR-BOUND: Zn+2
coiled coil {74-1348}
MOTIF: lysine-rich region {397-758}
MOTIF: lysine residue (SEVERAL)
lysine-rich region {937-1032}
MOTIF: lysine residue (SEVERAL)
lysine-rich region {1093-1231}
MOTIF: lysine residue (SEVERAL)
Zn finger Fyve-type
SITE: 1352-1410
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 605070
UniProt Q15075
Pfam PF01363
Entrez Gene 8411
Kegg hsa:8411
References
UniProt :accession Q15075