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edonerpic (T-817)
Contraindications:
- of no benefit in treating patients with mild-to-moderate Alzheimer's disease [1]
Mechanism of action:
- unclear
- may target opioid sigma receptors in the brain
- may activate microglia to clear amyloid
- in animal models, attenuates toxic effect of beta-amyloid
Clinical trials:
- NOBLE trial reported at AAIC 2017 [1]
General
nootropic agent
References
- Fiore K
Novel Drug Doesn't Help Cognition in Alzheimer's - Questions
about mechanism of action remain.
MedPage Today. July 19, 2017
https://www.medpagetoday.com/MeetingCoverage/AAIC/66717