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endothelin-1 receptor; endothelin A receptor; hET-AR; ETA-R; ET-A (EDNRA, ETA, ETRA)
Function:
- receptor for endothelin-1
- mediates its action by association with G proteins that activate a phosphatidylinositol-Ca+2 second messenger system
- The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3
- interacts with HDAC7 & HTATIP
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Alternative splicing: named isoforms=4
Expression:
- isoforms 1, 3 4 are expressed in a variety of tissues: aorta, cerebellum > lung, atrium, cerebral cortex > placenta, kidney, adrenal gland, duodenum, colon, ventricle & liver; no expression in umbilical vein endothelial cells
- within the placenta, isoforms 1,2,3 & 4 are expressed in the villi & stem villi vessels
General
endothelin receptor
glycoprotein
Properties
SIZE: entity length = 427 aa
MW = 49 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-20}
exoplasmic domain {21-80}
MOTIF: N-glycosylation site {N29}
N-glycosylation site {N62}
transmembrane domain {81-102}
cytoplasmic loop {103-112}
transmembrane domain {113-132}
exoplasmic loop {133-159}
MOTIF: cysteine residue {C158}
MODIFICATION: cysteine residue {C239}
transmembrane domain {160-181}
cytoplasmic loop {182-205}
transmembrane domain {206-229}
exoplasmic loop {230-256}
MOTIF: cysteine residue {C239}
MODIFICATION: cysteine residue {C158}
transmembrane domain {257-278}
cytoplasmic loop {279-306}
transmembrane domain {307-328}
exoplasmic loop {329-347}
transmembrane domain {348-372}
cytoplasmic domain {373-427}
Database Correlations
OMIM 131243
UniProt P25101
Pfam PF00001
Entrez Gene 1909
Kegg hsa:1909
References
UniProt :accession P25101